ABSTRACT
Objective To observe the effect of saline gauze tamponade of calculus bovis sativus on the level of IL-6 and IL-8 in the tissue of patients with perianal abscess after operation,and to explore its possible mechanism of action in promoting wound healing.Methods Patients with 84 cases of anal abscess surgery,were randomly divided into treatment group(n=42)and control group(n=42).Treatment group calculus bovis sativus research pressed into powder,take 0.10~0.15g evenly scattered in the saline gauze on the wound packing,the control group was treated with physiological saline gauze wound.After treatment,3,7 and 10d were treated with local granulation tissue about 0.2cm×0.2cm×0.1cm size,the IL-6 and IL-8 cytokines in local tissues were detected by enzyme-linked immunosorbent assay.Results There was no significant difference in the expression of IL-6 and IL-8 between the two groups 3 days after treatment(P>0.05),IL-6 and IL-8 in the treatment group(7,10d)were significantly lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Calculus bovis sativus in the treatment group,IL-6 and IL-8 levels were significantly lower than those of the control group,indicating that calculus bovis sativus can reduce local inflammation response,promote healing of wound after perianal abscess operation.
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Objective To observe the effects of recombinant human epidermal growth factor ( rhEGF)on wound healing of perianal abscess after operation. Methods A total of 112 cases of perianal abscess after operation were randomly divided into the study group( n=56 )and control group( n=56 ). Patients in the control group were disinfected routinely and treated by metronidazole or rivanol. In the stud-y group,patients were treated by rhEGF after disinfection of saline. Wound edema score was evaluated at the 3rd,7th and 10th day after the surgery. Healing time of the wound was recorded simultaneously. Re-sults Wound edema scores in the study group[(1. 20 ± 0. 70),(1. 00 ± 0. 67),and(1. 05 ± 0. 69)] were significantly lower than those of the control group[(1. 70 ± 0. 66),(1. 90 ± 0. 74),and(1. 70 ± 0. 73)]at the 3rd,7th and 10th day after operation(P﹤0. 05). Conclusion rhEGF can promote wound healing obviously.
ABSTRACT
Objective To investigate the clinical effect of modified seton therapy with counterparts drainage on high anal fistula.Methods One hundred and forty-four patients with high anal fistula were randomly assigned to the observed group (modified seton therapy with counterparts drainage,74 cases) and the control group (the traditional high hanging line therapy,70 cases).The clinical efficacy,visual analogue scale (VAS),Wexner incontinence score,fecal incontinence quality of life index (FIQLI) score were compared.Results Observed group were cured with 40 cases,improved with 27 cases,ineffective with 7 cases,control group were cured with 25 cases,improved with 43 cases,ineffective with 2 cases,difference between two groups was statistically significant (P ＜ 0.01).The healing time in observed group was significantly shorter than that in control group(P＜ 0.01).The VAS after therapy 1,7 d in observed group was significantly lower than that in control group (P ＜ 0.05).The Wexner incontinence score,FIQLI score before therapy was no significant difference between two groups (P ＞0.05).The Wexner incontinence score,FIQLI-lifestyle score,FIQLI-depression/self-perception score,FIQLI-distress score after therapy 3 months in observed group was significantly higher than that before therapy and control group after therapy 3 months (P ＜ 0.05),there was no significant difference Wexner incontinence score and FIQLI score before therapy compared with therapy 3 months in control group (P ＞ 0.05).Conclusions Modified seton therapy with counterparts drainage may be a valid treatment for high anal fistula.The successful outcome is associated with significant improvement in quality of life.